The pathological hallmark in patients with painful neuropathies is a significant loss of intraepidermal nerve fibers (IENF density). While the skin biopsy procedure is fast and relatively simple, it is easy to make small but paramount mistakes. Additionally, it is imperative that laboratories who process and analyse skin punch biopsies follow published standardised guidelines to secure results of high accuracy and quality. There is an urgent need to take steps helping to secure laboratories around the world follow published guidelines in order to secure high quality results and homogeneity in methods. In this presentation, Páll Karlsson will, via pre-recorded video and short presentation, describe the dos and don´ts when taking skin biopsies and the subsequent treatment, making it ready for immunohistological staining.